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Evidence Synthesis

Everything on Aqrab tagged Evidence Synthesis — grouped into one landing page so readers can go deeper by problem family instead of bouncing around the archive blind.

Evidence SynthesisMeta-analysisMethods Critique

Prediction Intervals in Meta-analysis: The Average Is Not Your Next Setting

A practical guide to why a precise pooled mean can coexist with a wide range of effects in similar settings—and when prediction intervals are unstable.

2026-10-11·7 min read
Evidence SynthesisMeta-analysisMethods Critique

Standardized Mean Differences: When 0.4 SD Still Needs Clinical Units

A practical guide to standardized mean differences in meta-analysis. Learn why the denominator depends on the study population, why generic effect-size labels do not establish clinical importance, and how to back-translate an SMD without hiding the assumptions.

2026-10-01·12 min read
Evidence SynthesisClinical TrialsMethods Critique

Estimands in Meta-Analysis: When a Shared PICO Still Pools Different Questions

A practical guide to estimands in meta-analysis. Learn how treatment-policy and hypothetical strategies can make trials with the same PICO answer different questions, and how to audit the pool before combining effects.

2026-08-31·14 min read
Evidence SynthesisClinical AIMethods Critique

AI Literature Search: Why Plausible Citations Are Not Evidence Coverage

A practical guide to auditing AI literature search in clinical research. Separate valid citations from evidence coverage, measure retrieval recall, and demand a reproducible search trail.

2026-08-26·14 min read
Evidence SynthesisGuideline MethodsMethods Critique

Transitivity in Network Meta-Analysis: When Indirect Comparisons Pretend the Trials Were Exchangeable

A practical guide to transitivity in network meta-analysis for clinical researchers. Covers effect modifiers, shared comparators, indirect comparison failure modes, and what reviewers should demand before trusting rankings.

2026-07-02·16 min read

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